Metamizole Injectable: Dosing and Precautions
Metamizole injectable guidance for pain and fever, with serious agranulocytosis and anaphylaxis warnings.
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Source reviewed
source date listed on the source page
Guide category
Potentially dangerous, obsolete, or ineffective
Safety boundary
Prescription medicine information for clinician-guided use.
Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.
Use restrictions
Given the potentially serious adverse effects and that safer alternatives exist, this drug should not be prescribed as first choice treatment.
Therapeutic action
Analgesic, antipyretic.
Indications
Pain, fever.
Forms and strengths, route of administration
1 g in 2 ml ampoule (500 mg/ml) for IM, SC or slow IV injection or infusion.
Dosage
Adult: 500 mg every 8 hours if necessary.
Duration
As short as possible.
Contra-indications, adverse effects, precautions
- May cause severe agranulocytosis, potentially fatal, regardless of dose or duration of treatment.
- May cause allergic reactions and anaphylactic shock.
- Pregnancy: contraindicated.
- Breast-feeding: contraindicated.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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