1 May 2026Potentially dangerous, obsolete, or ineffective
Metamizole = dipyrone = noramidopyrine injectable
Metamizole injectable guidance for pain and fever, with serious agranulocytosis and anaphylaxis warnings.
Prescription under medical supervision
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Use restrictions
Given the potentially serious adverse effects and that safer alternatives exist, this drug should not be prescribed as first choice treatment.
Therapeutic action
Analgesic, antipyretic.
Indications
Pain, fever.
Forms and strengths, route of administration
1 g in 2 ml ampoule (500 mg/ml) for IM, SC or slow IV injection or infusion.
Dosage
Adult: 500 mg every 8 hours if necessary.
Duration
As short as possible.
Contra-indications, adverse effects, precautions
- May cause severe agranulocytosis, potentially fatal, regardless of dose or duration of treatment.
- May cause allergic reactions and anaphylactic shock.
- Pregnancy: contraindicated.
- Breast-feeding: contraindicated.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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