1 May 2026Potentially dangerous, obsolete, or ineffective
Amodiaquine = AQ oral
Amodiaquine guidance for malaria treatment when used with artesunate, with key interaction and prior-toxicity precautions.
Prescription under medical supervision
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Use restrictions
Do not administer the combination artesunate-amodiaquine as separate tablets. Use co-formulated tablets.
Therapeutic action
Antimalarial.
Indications
- Treatment of uncomplicated falciparum malaria, in combination with artesunate.
- Treatment of uncomplicated malaria due to other Plasmodium species, in combination with artesunate, when chloroquine cannot be used.
- Completion treatment following parenteral therapy for severe malaria, in combination with artesunate.
Forms and strengths
200 mg amodiaquine hydrochloride tablet, containing 153 mg amodiaquine base.
Dosage and duration
Child and adult: 10 mg base/kg once daily for 3 days, in combination with artesunate.
Contra-indications, adverse effects, precautions
- Do not administer in the event of previous severe adverse reaction to treatment with amodiaquine such as hypersensitivity reaction, hepatitis, leucopenia, or agranulocytosis.
- Do not administer to patients taking efavirenz.
- May cause gastrointestinal disturbances, pruritus, cough, and insomnia.
- Pregnancy: no contra-indication.
- Breast-feeding: no contra-indication.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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