Amodiaquine Oral: Dosing and Precautions
Amodiaquine guidance for malaria treatment when used with artesunate, with key interaction and prior-toxicity precautions.
Also searched as
Source reviewed
source date listed on the source page
Guide category
Potentially dangerous, obsolete, or ineffective
Safety boundary
Prescription medicine information for clinician-guided use.
Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.
Use restrictions
Do not administer the combination artesunate-amodiaquine as separate tablets. Use co-formulated tablets.
Therapeutic action
Antimalarial.
Indications
- Treatment of uncomplicated falciparum malaria, in combination with artesunate.
- Treatment of uncomplicated malaria due to other Plasmodium species, in combination with artesunate, when chloroquine cannot be used.
- Completion treatment following parenteral therapy for severe malaria, in combination with artesunate.
Forms and strengths
200 mg amodiaquine hydrochloride tablet, containing 153 mg amodiaquine base.
Dosage and duration
Child and adult: 10 mg base/kg once daily for 3 days, in combination with artesunate.
Contra-indications, adverse effects, precautions
- Do not administer in the event of previous severe adverse reaction to treatment with amodiaquine such as hypersensitivity reaction, hepatitis, leucopenia, or agranulocytosis.
- Do not administer to patients taking efavirenz.
- May cause gastrointestinal disturbances, pruritus, cough, and insomnia.
- Pregnancy: no contra-indication.
- Breast-feeding: no contra-indication.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
Rate this guide
Be the first to rate this guide.