Diphtheria-tetanus-pertussis vaccine (DTP)

Use restrictions

This vaccine has been replaced by the pentavalent DTP/Hepatitis B/Hib vaccine.

Indications

Prevention of diphtheria, tetanus and pertussis in children under 7 years (primary vaccination and booster dose).

Composition, forms, route of administration

Trivalent vaccine combining diphtheria toxoid, tetanus toxoid and whole-cell or acellular pertussis vaccine.

Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children under 2 years and in the deltoid muscle in children 2 years and over.

Dosage and vaccination schedule

Child: 0.5 ml per dose.

• Primary vaccination: 3 doses 4 weeks apart, preferably before the age of 6 months.
• It is recommended to administer the first dose at 6 weeks of age, the second dose at 10 weeks of age and the third dose at 14 weeks of age.
• If a child has not been vaccinated at 6 weeks of age, start vaccination as soon as possible.
• Booster: one dose between 12 and 23 months.

Contra-indications, adverse effects, precautions

• Do not administer in the event of allergic reactions to a previous dose of DTP vaccine or evolving neurological disease such as encephalopathy or uncontrolled epilepsy.
• Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
• May cause mild local reactions at the injection site, fever, fatigue, malaise, and rarely anaphylactic reactions or seizures.
• Respect an interval of 4 weeks between each dose of primary vaccination.
• If administered simultaneously with other vaccines, use different syringes and injection sites.