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1 May 2026Drugs for external use and antisepticsSource update: January 2026

Chlorhexidine 5%, concentrated solution

Concentrated chlorhexidine guidance for diluted use on small or superficial wounds and burns.

This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.

Therapeutic action

Antiseptic.

Indications

Antisepsis of small or superficial wounds and burns.

Forms and strengths

5% chlorhexidine (di)gluconate concentrated solution, to be diluted before use.

Preparation

Prepare diluted solutions with clean water, or sterile water:

  • For one litre of 0.5% solution: 100 ml of 5% solution plus 900 ml of water.
  • For one litre of 0.05% solution: 10 ml of 5% solution plus 990 ml of water.

Use

Apply diluted solution to small or superficial wounds and burns.

Contra-indications, adverse effects, precautions

  • Do not use undiluted solution.
  • Do not use with soap, creams, lotions, or a different antiseptic.
  • Do not bring in contact with body cavities, brain and meninges, eyes, middle ear, or inner ear.
  • Avoid use on mucous membranes, especially genital mucous membranes.
  • May cause skin and mucous membrane irritation and rarely hypersensitivity reactions.
  • In case of contact with eyes, rinse immediately with water.
  • Pregnancy and breast-feeding: no contra-indication.
  • Once diluted, use the solution within 24 hours because of the risk of contamination.

Source

MSF Essential drugs practical guidelines (January 2026)

This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.

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