31 August 2026Chapter 3: Gastrointestinal disordersPDF page 125
Stomatitis
Full paraphrased clinical guide to mouth inflammation, hydration risk, feeding support, hygiene, and major causes.
This guide supports clinical education and care navigation. It does not replace bedside judgement, emergency care, specialist advice, or local treatment protocol.
Seek urgent care
- Inability to drink or feed, dehydration, severe pain, extensive mouth ulcers, breathing difficulty, or altered consciousness.
- Mouth lesions in an infant refusing breastfeeds or unable to suck.
- Frequent, extensive, or recurrent lesions suggesting HIV, diabetes, severe malnutrition, or another underlying illness.
Overview
Stomatitis is inflammation of the mouth mucosa. Causes include fungal, viral, and bacterial infection, vitamin deficiency, trauma, and other irritation.
Painful or prolonged stomatitis can reduce intake, causing dehydration or undernutrition, especially in children.
Initial care in all cases
- Maintain hydration and feeding.
- Offer soft, non-acidic foods that do not irritate the mouth.
- Use nasogastric feeding for a short period if pain prevents eating and clinical support is available.
- Keep the mouth clean to prevent complications and recurrence.
- Examine the mouth of infants with breast refusal or difficulty sucking.
Major causes to identify
- Oral or oropharyngeal candidiasis.
- Primary or recurrent oral herpes.
- Other infectious causes such as pharyngitis, diphtheria, or measles.
- Scurvy from vitamin C deficiency.
- Other nutritional deficiencies, including riboflavin, niacin, pyridoxine, and iron deficiency.
- Trauma, caustic or thermal injury, medicine reaction, severe systemic infection, HIV, diabetes, and severe malnutrition should be considered when the presentation is extensive, recurrent, or atypical.
Complications, prevention, and handover
- Complications include dehydration, undernutrition, secondary bacterial infection, inability to breastfeed, missed diphtheria or measles, oesophageal candidiasis, eye involvement in herpes, and severe underlying disease.
- Prevention depends on oral hygiene, safe feeding, correcting nutritional deficiencies, reducing unnecessary antibiotics, rinsing after high-dose inhaled corticosteroids, vaccination for relevant infections, and management of HIV, diabetes, or malnutrition.
- Handover should include duration, lesion type and distribution, pain severity, feeding/drinking ability, hydration status, infant sucking, fever, recurrence, immune/nutrition risks, suspected cause, treatment started, and follow-up plan.
Medicines in this guide
Oral rehydration salts = ORSFluid support if painful mouth lesions reduce intake or dehydration risk appears.Paracetamol = acetaminophen oralPain or fever treatment when needed.Nystatin oralTreatment option when oral candidiasis is identified.Miconazole oral gelAlternative local treatment for oral candidiasis where age and swallowing safety allow.Aciclovir oralUsed for severe primary herpetic gingivostomatitis within the treatment window.Ascorbic acid = Vitamin C oralTreatment and prevention of scurvy-related stomatitis.Ferrous salts oralRelevant when iron deficiency contributes to angular stomatitis.
Source
MSF Clinical guidelines - Diagnosis and treatment manual (December 2024)
This page is a paraphrased clinician-oriented guide derived from the source topic on PDF page 125. Medicine-specific details should be checked against local protocol and the linked drug-information pages.
