1 May 2026Vaccines, immunoglobulins and antisera
Typhoid conjugate vaccine (TCV)
TCV guidance for prevention of typhoid fever in endemic areas and outbreak or emergency campaigns.
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Indications
Prevention of typhoid fever in children from 6 months and adults up to 45 years of age in endemic areas or during mass immunisation campaigns in outbreaks or humanitarian emergency contexts based on risk assessment.
Composition, forms, route of administration
- Typhoid polysaccharide conjugate vaccine.
- Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children under 2 years and into the deltoid muscle in children 2 years and over.
- Do not administer into the gluteal muscle.
Dose and vaccination schedule
Child and adult: 0.5 ml single dose.
Routine vaccination
- Child at 9 months or during the second year of life: one single dose at the same time as other recommended vaccines. Follow national recommendations.
Catch-up vaccination
- Child up to 15 years: one single dose. Follow national recommendations.
Contra-indications, adverse effects, precautions
- Do not administer in case of allergic reactions to any component of the vaccine.
- Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
- May cause mild reactions at the injection site, fever, headache, myalgia, and rarely anaphylactic reactions.
- If administered simultaneously with other vaccines, use different syringes and injection sites.
- Pregnancy and breast-feeding: no contra-indication.
- Typhoid conjugate vaccine does not protect against Salmonella Paratyphi or other non-typhi salmonella.
- Once opened, store vial between 2 and 8 degrees Celsius for 6 hours maximum.
- Shake before use to homogenise the vaccine.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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