Typhoid Conjugate Vaccine (TCV): Schedule and Precautions
TCV guidance for prevention of typhoid fever in endemic areas and outbreak or emergency campaigns.
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Source reviewed
source date listed on the source page
Guide category
Vaccines, immunoglobulins and antisera
Safety boundary
Educational medicine information, not personal medical advice.
Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.
Indications
Prevention of typhoid fever in children from 6 months and adults up to 45 years of age in endemic areas or during mass immunisation campaigns in outbreaks or humanitarian emergency contexts based on risk assessment.
Composition, forms, route of administration
- Typhoid polysaccharide conjugate vaccine.
- Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children under 2 years and into the deltoid muscle in children 2 years and over.
- Do not administer into the gluteal muscle.
Dose and vaccination schedule
Child and adult: 0.5 ml single dose.
Routine vaccination
- Child at 9 months or during the second year of life: one single dose at the same time as other recommended vaccines. Follow national recommendations.
Catch-up vaccination
- Child up to 15 years: one single dose. Follow national recommendations.
Contra-indications, adverse effects, precautions
- Do not administer in case of allergic reactions to any component of the vaccine.
- Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
- May cause mild reactions at the injection site, fever, headache, myalgia, and rarely anaphylactic reactions.
- If administered simultaneously with other vaccines, use different syringes and injection sites.
- Pregnancy and breast-feeding: no contra-indication.
- Typhoid conjugate vaccine does not protect against Salmonella Paratyphi or other non-typhi salmonella.
- Once opened, store vial between 2 and 8 degrees Celsius for 6 hours maximum.
- Shake before use to homogenise the vaccine.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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