Tranexamic acid oral

Therapeutic action

Antifibrinolytic.

Indications

Abnormal uterine bleeding, especially functional uterine bleeding unrelated to pregnancy.

Forms and strengths

• 500 mg tablet.

Dose and duration

• Adolescent and adult: 1 g 3 times daily, maximum 1 g 4 times daily, until bleeding stops, maximum 5 days.

Contra-indications, adverse effects, precautions

• Do not administer in patients with, or with a history of, venous or arterial thromboembolic disorders, severe renal impairment, or history of seizures.
• Reduce dosage in patients with mild to moderate renal impairment because of the risk of accumulation.
• May cause gastrointestinal disturbances, seizures with high doses, visual disturbances, and allergic reactions.
• Avoid combination with drugs that increase the risk of thromboembolism. Concomitant use of oestrogens should be carefully considered on a case-by-case basis.
• Pregnancy: this drug is not indicated in the event of bleeding during pregnancy.
• Breast-feeding: no contra-indication.