Tinidazole Oral: Dosing and Precautions
Tinidazole guidance for amoebiasis, giardiasis, trichomoniasis, bacterial vaginitis, and anaerobic infections.
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Guide category
Oral drugs
Safety boundary
Prescription medicine information for clinician-guided use.
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Therapeutic action
Antiprotozoal, antibacterial (group of nitroimidazoles).
Indications
- Amoebiasis, giardiasis, trichomoniasis.
- Bacterial vaginitis.
- Infections due to anaerobic bacteria such as Clostridium and Bacteroides species.
Forms and strengths
- 500 mg tablet.
Dose and duration
Amoebiasis
The treatment lasts 3 days in intestinal amoebiasis and 5 days in hepatic amoebiasis.
- Child: 50 mg/kg once daily, maximum 2 g daily.
- Adult: 2 g once daily.
Giardiasis, trichomoniasis and bacterial vaginitis
In the event of trichomoniasis, also treat the sexual partner.
- Child: 50 mg/kg single dose, maximum 2 g.
- Adult: 2 g single dose.
Infections due to anaerobic bacteria
According to indication, tinidazole may be used in combination with other antibacterials; treatment duration depends on indication.
- Child over 12 years and adult: 2 g on D1 then 1 g once daily or 500 mg 2 times daily.
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to tinidazole or another nitroimidazole such as metronidazole or secnidazole.
- May cause gastrointestinal disturbances and, rarely, allergic reactions, brownish urine, headache, and dizziness.
- Risk of antabuse reaction when combined with alcohol.
- Administer with caution in patients taking oral anticoagulants, lithium, or phenytoin.
- Pregnancy: no contra-indication; divide into smaller doses and avoid prolonged use.
- Breast-feeding: significantly excreted in milk; divide into smaller doses and avoid prolonged use.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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