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Therapeutic actionIndicationsForms and strengthsDoseDurationContra-indications, adverse effects, precautions
1 May 2026Oral drugsSource update: November 2022

Tenofovir Oral: Dosing and Precautions

Tenofovir guidance for HIV infection and chronic hepatitis B, with renal and bone precautions.

Also searched as

TDF oralTenofovir disoproxil fumarateTenofovir
Prescription under medical supervision

Source reviewed

November 2022

Guide category

Oral drugs

Safety boundary

Prescription medicine information for clinician-guided use.

Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.

This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.

Therapeutic action

Antiretroviral, HIV nucleotide reverse transcriptase inhibitor.

Indications

  • HIV infection with or without chronic hepatitis B coinfection, in combination with other antiretrovirals.
  • Chronic hepatitis B without HIV coinfection, in monotherapy.

Forms and strengths

  • 300 mg tablet, equivalent to 245 mg of tenofovir disoproxil.

Dose

  • Child 35 kg and over and adult: 300 mg once daily.

Duration

Depending on the efficacy and tolerance of tenofovir.

Contra-indications, adverse effects, precautions

  • Administer with caution and monitor use in patients with renal impairment or osteoporosis. In the event of deterioration of renal function, switch to another antiretroviral.
  • Avoid combination, or closely monitor renal function, with nephrotoxic drugs such as aminoglycosides, amphotericin B, pentamidine, and NSAIDs.
  • May cause gastrointestinal disturbances, dizziness, fatigue, skin rash, renal impairment, bone loss, and pancreatitis.
  • Pregnancy: no contra-indication.

Source

MSF Essential drugs practical guidelines (January 2026)

This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.

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