Streptomycin injectable

Therapeutic action

Antibacterial, group of aminoglycosides.

Indications

• Alternative to gentamicin in plague.
• Brucellosis, in combination with doxycycline.

Forms and strengths, route of administration

Given the risk of renal and auditory toxicity, do not prolong treatment unnecessarily.

• Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 3.2 ml of water for injection to obtain a 250 mg/ml solution, for IM injection.
• Do not administer by IV injection.

Dose

Duration

• Plague: 10 to 14 days.
• Brucellosis: 2 weeks.

Contra-indications, adverse effects, precautions

• Do not administer to patients with allergy to aminoglycosides.
• Administer with caution to patients with history of renal, vestibular, or auditory problems.
• Reduce the dose in patients with renal impairment.
• May cause irreversible ototoxicity, nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade, and rarely allergic reactions.
• Stop treatment in the event of dizziness, tinnitus, or hearing loss.
• Drink sufficient liquid to limit the risk of renal toxicity.
• Do not combine with another aminoglycoside.
• Avoid or monitor combination with furosemide, amphotericin B, vancomycin, and neuromuscular blockers.
• Pregnancy: contraindicated.
• Breast-feeding: no contra-indication.