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Therapeutic actionIndicationsForms and strengths, route of administrationDoseDurationContra-indications, adverse effects, precautions
1 May 2026Injectable drugsSource update: September 2022

Streptomycin Injectable: Dosing and Precautions

Streptomycin guidance as an alternative in plague and for brucellosis with doxycycline.

Also searched as

Streptomycin
Prescription under medical supervision

Source reviewed

September 2022

Guide category

Injectable drugs

Safety boundary

Prescription medicine information for clinician-guided use.

Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.

This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.

Therapeutic action

Antibacterial, group of aminoglycosides.

Indications

  • Alternative to gentamicin in plague.
  • Brucellosis, in combination with doxycycline.

Forms and strengths, route of administration

Given the risk of renal and auditory toxicity, do not prolong treatment unnecessarily.

  • Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 3.2 ml of water for injection to obtain a 250 mg/ml solution, for IM injection.
  • Do not administer by IV injection.

Dose

Plague

  • Child: 15 mg/kg, maximum 1 g, every 12 hours.
  • Adult: 1 g every 12 hours.

Brucellosis

  • Adult: 1 g once daily.

Duration

  • Plague: 10 to 14 days.
  • Brucellosis: 2 weeks.

Contra-indications, adverse effects, precautions

  • Do not administer to patients with allergy to aminoglycosides.
  • Administer with caution to patients with history of renal, vestibular, or auditory problems.
  • Reduce the dose in patients with renal impairment.
  • May cause irreversible ototoxicity, nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade, and rarely allergic reactions.
  • Stop treatment in the event of dizziness, tinnitus, or hearing loss.
  • Drink sufficient liquid to limit the risk of renal toxicity.
  • Do not combine with another aminoglycoside.
  • Avoid or monitor combination with furosemide, amphotericin B, vancomycin, and neuromuscular blockers.
  • Pregnancy: contraindicated.
  • Breast-feeding: no contra-indication.

Source

MSF Essential drugs practical guidelines (January 2026)

This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.

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