Sodium Bicarbonate 8.4% Injectable: Precautions
Hypertonic sodium bicarbonate guidance for severe metabolic acidosis under close supervision.
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Source reviewed
October 2024
Guide category
Injectable drugs
Safety boundary
Prescription medicine information for clinician-guided use.
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Indications
Severe metabolic acidosis.
Forms and strengths
10 ml ampoule.
Composition
- Sodium bicarbonate: 8.4 g per 100 ml.
- Hypertonic solution.
- Sodium: 10 mmol (10 mEq) per 10 ml ampoule.
- Bicarbonate: 10 mmol (10 mEq) per 10 ml ampoule.
Contra-indications, adverse effects, precautions
- Do not use in case of alkalosis or respiratory acidosis.
- Do not administer hypertonic solutions by IM or SC route.
- Administer under close medical supervision, by slow direct IV injection diluted in 5% glucose or by continuous infusion in 5% glucose.
- Do not add penicillins, chloramphenicol, aspirin, atropine, calcium, insulin, vitamins, and similar drugs to sodium bicarbonate solution.
- Contains a high concentration of bicarbonate and sodium ions. Its use is rarely justified in metabolic acidosis caused by dehydration.
- Inaccurate administration may induce hypernatraemia and hypokalaemia.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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