Rifapentine = P oral

Therapeutic action

Antituberculosis antibacterial (bactericidal activity).

Indications

Latent tuberculosis, in combination with isoniazid.

Forms and strengths

• 150 mg tablet.
• 300 mg tablet.

Dose and duration

Contra-indications, adverse effects, precautions

• Do not administer to patients with jaundice, hypersensitivity to rifamycins, or history of severe haematological disorders during a previous treatment with rifamycins.
• Do not administer the weekly regimen to children under 2 years or the daily regimen to children under 13 years.
• Avoid or administer with caution to patients with hepatic disorders.
• May cause orange-red discoloration of body secretions, gastrointestinal disturbances, rarely hepatotoxicity, headache, influenza-like symptoms, haematological disorders, cutaneous reactions, and hypersensitivity reactions.
• If signs of hepatotoxicity develop, rifapentine should be discontinued until symptoms resolve.
• Rifapentine reduces the effect of many drugs including antimicrobials, anticonvulsants, some antiretrovirals, some hormones, antidiabetics, corticosteroids, direct-acting antivirals for chronic hepatitis C, and warfarin.
• Do not administer in patients on protease inhibitors or nevirapine.
• In women using contraception, use medroxyprogesterone or an intrauterine device.
• With concomitant fluconazole, administer each drug 12 hours apart.
• Pregnancy and breast-feeding: not recommended because safety is not established.
• Tablets can be crushed and mixed with a small amount of food.

Dosage and duration