Pyridoxine Oral: Neuropathy Prevention and Treatment
Pyridoxine guidance for prevention and treatment of isoniazid-induced peripheral neuropathy.
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Guide category
Oral drugs
Safety boundary
Educational medicine information, not personal medical advice.
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Therapeutic action
Vitamin.
Indications
Prevention and treatment of isoniazid-induced peripheral neuropathy.
Forms and strengths
- 25 mg tablet.
- Also comes in 10 mg and 50 mg tablets.
Dose
Prevention of isoniazid neuropathy
- Child under 5 kg: 5 mg once daily.
- Child over 5 kg and adult: 10 mg once daily.
Treatment of isoniazid neuropathy
- Child: 50 mg once daily.
- Adult: 50 mg 3 times daily.
Duration
- Prevention: as long as treatment with isoniazid continues.
- Treatment: according to clinical response, in general 3 weeks or less, then preventive dose as long as treatment with isoniazid continues.
Contra-indications, adverse effects, precautions
- No contra-indication.
- May cause peripheral neuropathy in the event of prolonged use with doses of 200 mg daily or more.
- Pregnancy: no contra-indication.
- Breast-feeding: no contra-indication.
- In children receiving isoniazid prophylaxis or treatment for tuberculosis, concomitant administration of pyridoxine at preventive dosage is recommended for children under 5 years and all children infected with HIV.
Source
MSF Essential drugs practical guidelines (January 2026)
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