1 May 2026Oral drugs
Pyridoxine = Vitamin B6 oral
Pyridoxine guidance for prevention and treatment of isoniazid-induced peripheral neuropathy.
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Therapeutic action
Vitamin.
Indications
Prevention and treatment of isoniazid-induced peripheral neuropathy.
Forms and strengths
- 25 mg tablet.
- Also comes in 10 mg and 50 mg tablets.
Dose
Prevention of isoniazid neuropathy
- Child under 5 kg: 5 mg once daily.
- Child over 5 kg and adult: 10 mg once daily.
Treatment of isoniazid neuropathy
- Child: 50 mg once daily.
- Adult: 50 mg 3 times daily.
Duration
- Prevention: as long as treatment with isoniazid continues.
- Treatment: according to clinical response, in general 3 weeks or less, then preventive dose as long as treatment with isoniazid continues.
Contra-indications, adverse effects, precautions
- No contra-indication.
- May cause peripheral neuropathy in the event of prolonged use with doses of 200 mg daily or more.
- Pregnancy: no contra-indication.
- Breast-feeding: no contra-indication.
- In children receiving isoniazid prophylaxis or treatment for tuberculosis, concomitant administration of pyridoxine at preventive dosage is recommended for children under 5 years and all children infected with HIV.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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