Potassium Chloride Sustained-Release Oral: Dosing
Sustained-release potassium chloride guidance for diuretic-induced hypokalaemia during longer-term replacement.
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Guide category
Oral drugs
Safety boundary
Prescription medicine information for clinician-guided use.
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Therapeutic action
Potassium supplement.
Indications
Hypokalaemia induced by thiazide diuretics such as hydrochlorothiazide and loop diuretics such as furosemide.
Forms and strengths
- 600 mg potassium chloride sustained-release tablet providing 8 mmol of potassium.
Dose
Do not exceed indicated doses if potassium serum levels cannot be measured.
- Adult: 15 to 25 mmol daily, corresponding to 1 tablet 2 to 3 times daily.
Duration
According to clinical response and duration of diuretic treatment.
Contra-indications, adverse effects, precautions
- Administer with caution and reduce dosage in elderly patients and patients with renal impairment because of the risk of hyperkalaemia.
- Do not combine with spironolactone and angiotensin-converting-enzyme inhibitors such as enalapril.
- May cause hyperkalaemia, gastroduodenal ulcerations, diarrhoea, nausea, and vomiting.
- Pregnancy: no contra-indication.
- Breast-feeding: no contra-indication.
- Take with or at the end of meals to reduce the risk of gastrointestinal ulcerations.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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