1 May 2026Injectable drugs
Ondansetron injectable
Ondansetron injectable guidance for postoperative nausea and vomiting in children and adults.
Prescription under medical supervision
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Therapeutic action
Antiemetic (serotonin 5-HT3 receptor antagonist).
Indications
- Prevention of post-operative nausea and vomiting in children.
- Treatment of post-operative nausea and vomiting.
Forms and strengths, route of administration
- 4 mg ampoule (2 mg/ml, 2 ml) for slow IV injection over 3 to 5 minutes.
Dose and duration
Do not exceed 4 mg per injection and 3 injections per 24 hours.
Prevention of post-operative nausea and vomiting
- Child over 1 month: 0.1 mg/kg at the end of surgery, maximum 4 mg per injection.
Treatment of nausea and vomiting
- Child over 1 month with no prophylactic dose received: 0.1 mg/kg every 8 hours if necessary.
- Child over 1 month with a prophylactic dose received and late postoperative vomiting 6 hours or more after surgery: 0.1 mg/kg every 6 hours if necessary.
- Adult: 4 mg every 8 hours if necessary, maximum 3 injections per 24 hours.
Contra-indications, adverse effects, precautions
- Do not administer to children less than 1 month of age.
- Administer with caution and monitor use in patients with congenital long QT syndrome, cardiac insufficiency, and bradycardia.
- Reduce the dose in patients with hepatic failure to a maximum of 8 mg daily.
- May cause headache, sensation of flushing or warmth, hiccups, constipation, heart rhythm disorders, QT interval prolongation, extrapyramidal reactions, seizures, and severe cutaneous allergic reactions.
- Avoid or monitor combination with drugs that prolong the QT interval, serotonergics, enzyme inducers, and tramadol.
- Pregnancy: avoid during the first trimester and do not recommend for nausea and vomiting of pregnancy.
- Breast-feeding: not recommended.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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