Ondansetron Injectable: Dosing and Precautions
Ondansetron injectable guidance for postoperative nausea and vomiting in children and adults.
Also searched as
Source reviewed
source date listed on the source page
Guide category
Injectable drugs
Safety boundary
Prescription medicine information for clinician-guided use.
Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.
Therapeutic action
Antiemetic (serotonin 5-HT3 receptor antagonist).
Indications
- Prevention of post-operative nausea and vomiting in children.
- Treatment of post-operative nausea and vomiting.
Forms and strengths, route of administration
- 4 mg ampoule (2 mg/ml, 2 ml) for slow IV injection over 3 to 5 minutes.
Dose and duration
Do not exceed 4 mg per injection and 3 injections per 24 hours.
Prevention of post-operative nausea and vomiting
- Child over 1 month: 0.1 mg/kg at the end of surgery, maximum 4 mg per injection.
Treatment of nausea and vomiting
- Child over 1 month with no prophylactic dose received: 0.1 mg/kg every 8 hours if necessary.
- Child over 1 month with a prophylactic dose received and late postoperative vomiting 6 hours or more after surgery: 0.1 mg/kg every 6 hours if necessary.
- Adult: 4 mg every 8 hours if necessary, maximum 3 injections per 24 hours.
Contra-indications, adverse effects, precautions
- Do not administer to children less than 1 month of age.
- Administer with caution and monitor use in patients with congenital long QT syndrome, cardiac insufficiency, and bradycardia.
- Reduce the dose in patients with hepatic failure to a maximum of 8 mg daily.
- May cause headache, sensation of flushing or warmth, hiccups, constipation, heart rhythm disorders, QT interval prolongation, extrapyramidal reactions, seizures, and severe cutaneous allergic reactions.
- Avoid or monitor combination with drugs that prolong the QT interval, serotonergics, enzyme inducers, and tramadol.
- Pregnancy: avoid during the first trimester and do not recommend for nausea and vomiting of pregnancy.
- Breast-feeding: not recommended.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
Rate this guide
Be the first to rate this guide.