Omeprazole Injectable: Dosing and Precautions
Omeprazole injectable guidance for peptic ulcer perforation when IV proton pump inhibition is needed.
Also searched as
Source reviewed
source date listed on the source page
Guide category
Injectable drugs
Safety boundary
Prescription medicine information for clinician-guided use.
Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.
Therapeutic action
Antiulcer drug (proton pump inhibitor).
Indications
Peptic ulcer perforation.
Forms and strengths, route of administration
- Powder for injection, 40 mg vial, to be dissolved in 100 ml of 0.9% sodium chloride or 5% glucose for IV infusion.
Dose
- Adult: 40 mg once daily to be administered over 20 to 30 minutes.
Duration
Change to oral treatment as soon as the patient can eat.
Contra-indications, adverse effects, precautions
- May cause headache, diarrhoea, skin rash, nausea, abdominal pain, and dizziness.
- Avoid combination with itraconazole and ketoconazole.
- Monitor combination with warfarin, digoxin, and phenytoin.
- Do not exceed 20 mg daily in patients with severe hepatic impairment.
- Pregnancy: no contra-indication.
- Breast-feeding: avoid, administer only if clearly needed.
- Only use 0.9% sodium chloride or 5% glucose for dilution.
- Injectable omeprazole is not included in the WHO list of essential medicines.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
Rate this guide
Be the first to rate this guide.