1 May 2026Injectable drugs
Omeprazole injectable
Omeprazole injectable guidance for peptic ulcer perforation when IV proton pump inhibition is needed.
Prescription under medical supervision
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Therapeutic action
Antiulcer drug (proton pump inhibitor).
Indications
Peptic ulcer perforation.
Forms and strengths, route of administration
- Powder for injection, 40 mg vial, to be dissolved in 100 ml of 0.9% sodium chloride or 5% glucose for IV infusion.
Dose
- Adult: 40 mg once daily to be administered over 20 to 30 minutes.
Duration
Change to oral treatment as soon as the patient can eat.
Contra-indications, adverse effects, precautions
- May cause headache, diarrhoea, skin rash, nausea, abdominal pain, and dizziness.
- Avoid combination with itraconazole and ketoconazole.
- Monitor combination with warfarin, digoxin, and phenytoin.
- Do not exceed 20 mg daily in patients with severe hepatic impairment.
- Pregnancy: no contra-indication.
- Breast-feeding: avoid, administer only if clearly needed.
- Only use 0.9% sodium chloride or 5% glucose for dilution.
- Injectable omeprazole is not included in the WHO list of essential medicines.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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