1 May 2026Oral drugsSource update: February 2024
Metoclopramide oral
Metoclopramide guidance for symptomatic nausea and vomiting in adults, with strict duration and neurological safety limits.
Prescription under medical supervision
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Therapeutic action
Antiemetic (dopamine antagonist).
Indications
Symptomatic treatment of nausea and vomiting in adults.
Forms and strengths
- 10 mg tablet.
Dose
The interval between each dose should be at least 6 hours, even in the event of vomiting.
- Adult under 60 kg: 5 mg 3 times daily.
- Adult over 60 kg: 10 mg 3 times daily.
Duration
Maximum 5 days.
Contra-indications, adverse effects, precautions
- Do not administer to children under 18 years or to patients with gastrointestinal haemorrhage, obstruction, or perforation.
- Reduce the dose by half in patients with severe renal impairment.
- Administer with caution and monitor use in patients over 60 years and patients with epilepsy or Parkinson's disease.
- May cause drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures, allergic reactions, and rarely neuroleptic malignant syndrome requiring immediate discontinuation.
- Do not combine with levodopa because of antagonism.
- Avoid combination with CNS depressants.
- Avoid alcohol during treatment.
- Pregnancy: no contra-indication.
- Breast-feeding: no contra-indication.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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