Metoclopramide Oral: Dosing and Precautions
Metoclopramide guidance for symptomatic nausea and vomiting in adults, with strict duration and neurological safety limits.
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Source reviewed
February 2024
Guide category
Oral drugs
Safety boundary
Prescription medicine information for clinician-guided use.
Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.
Therapeutic action
Antiemetic (dopamine antagonist).
Indications
Symptomatic treatment of nausea and vomiting in adults.
Forms and strengths
- 10 mg tablet.
Dose
The interval between each dose should be at least 6 hours, even in the event of vomiting.
- Adult under 60 kg: 5 mg 3 times daily.
- Adult over 60 kg: 10 mg 3 times daily.
Duration
Maximum 5 days.
Contra-indications, adverse effects, precautions
- Do not administer to children under 18 years or to patients with gastrointestinal haemorrhage, obstruction, or perforation.
- Reduce the dose by half in patients with severe renal impairment.
- Administer with caution and monitor use in patients over 60 years and patients with epilepsy or Parkinson's disease.
- May cause drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures, allergic reactions, and rarely neuroleptic malignant syndrome requiring immediate discontinuation.
- Do not combine with levodopa because of antagonism.
- Avoid combination with CNS depressants.
- Avoid alcohol during treatment.
- Pregnancy: no contra-indication.
- Breast-feeding: no contra-indication.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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