Medroxyprogesterone Acetate Oral: Uses and Precautions
Oral medroxyprogesterone guidance for abnormal uterine bleeding, distinct from the injectable contraceptive form.
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Source reviewed
October 2021
Guide category
Oral drugs
Safety boundary
Prescription medicine information for clinician-guided use.
Kenza Health Hub presents this medicine page as structured health education. Check dose, route, interactions, pregnancy or breast-feeding considerations, and local protocol with a qualified clinician or pharmacist. Read our medical editorial policy.
Therapeutic action
Progestogen.
Indications
Abnormal uterine bleeding, especially functional uterine bleeding unrelated to pregnancy.
Forms and strengths
- 10 mg tablet.
Dose and duration
Persistent abnormal uterine bleeding despite tranexamic acid therapy or heavy bleeding when tranexamic acid is contraindicated
- Adolescent and adult: 20 mg 3 times daily for 7 days.
Long-term treatment of functional uterine bleeding
- Adult: 10 mg once daily, up to 30 mg once daily if necessary. Continue according to clinical response.
Contra-indications, adverse effects, precautions
- Do not administer to patients with breast cancer, severe hypertension, active thromboembolic disorders, uncontrolled or complicated diabetes, or severe or recent hepatic disease.
- May cause menstrual irregularities, amenorrhoea, menometrorrhagia, breast tenderness, headache, weight gain, acne, mood change, abdominal pain, and gastrointestinal disturbances.
- Pregnancy: contraindicated.
- Breast-feeding: no contra-indication.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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