1 May 2026Injectable drugsSource update: November 2022
Fluconazole injectable
Injectable fluconazole guidance for severe fungal infections when oral treatment is not possible.
Prescription under medical supervision
This guide page is for structured reference only and does not replace a clinician, pharmacist, or emergency review. Dose choice, route choice, interactions, and safety decisions still need professional judgment.
Therapeutic action
Antifungal.
Indications
- Cryptococcal meningitis, in combination with amphotericin B or flucytosine.
- Severe oesophageal candidiasis.
Forms and strengths, route of administration
- 200 mg in 100 ml bottle or bag, 2 mg/ml, for IV infusion.
Dose
Cryptococcal meningitis, in combination with amphotericin B or flucytosine
- Child 1 month and over: 12 mg/kg, maximum 800 mg, once daily administered over at least 20 minutes.
- Adult: 1200 mg once daily, administered over at least 10 minutes.
Severe oesophageal candidiasis
- Child 1 month and over: 3 to 6 mg/kg, maximum 200 mg, once daily.
- Adult: 200 mg once daily, maximum 400 mg.
Duration
Change to oral treatment as soon as possible.
Contra-indications, adverse effects, precautions
- Administer with caution to patients with hepatic or renal impairment and cardiac disorders.
- Reduce the dose by half in patients with renal impairment.
- May cause gastrointestinal disturbances, headache, skin reactions sometimes severe, anaphylactic reactions, severe hepatic disorders, haematological disorders, and cardiac disorders including QT prolongation.
- Stop treatment in the event of anaphylactic reaction, hepatic disorders, or severe skin reaction.
- Avoid or monitor combination with drugs that prolong the QT interval, warfarin, carbamazepine, phenytoin, rifabutin, benzodiazepines, calcium-channel blockers, certain antiretrovirals, and rifampicin.
- Pregnancy and breast-feeding: use only in severe or life-threatening infections, particularly during the first trimester of pregnancy.
- In neonates, administer every 72 hours if under 14 days old or every 48 hours if 14 days and over.
- Do not add any drug in the infusion bottle or bag.
Source
MSF Essential drugs practical guidelines (January 2026)
This page reproduces the structured reference information for this batch while leaving out the Storage and Remarks sections.
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