Clarithromycin Oral: Dosing and Precautions
Clarithromycin guidance for Helicobacter pylori eradication in combination therapy, with renal and QT precautions.
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Source reviewed
source date listed on the source page
Guide category
Oral drugs
Safety boundary
Prescription medicine information for clinician-guided use.
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Therapeutic action
Macrolide antibacterial.
Indications
Eradication of Helicobacter pylori, in combination with omeprazole and amoxicillin.
Forms and strengths
- 500 mg tablet.
Dose and duration
- Adult: 500 mg 2 times daily for 7 days.
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to clarithromycin or another macrolide.
- May cause headache, taste disturbances, insomnia, gastrointestinal disturbances, reversible hearing disorders, heart rhythm disorders including QT prolongation, and sometimes severe hypersensitivity reactions. In this event, stop treatment immediately.
- Administer with caution and reduce dosage by half in patients with severe renal impairment.
- Avoid combination with drugs that prolong the QT interval, including amiodarone, antimalarials, antipsychotics, efavirenz, fluconazole, fluoroquinolones, hydroxyzine, and ondansetron.
- Administer with caution and monitor combination with oral antidiabetics, atorvastatin, carbamazepine, daclatasvir, digoxin, phenytoin, and rifabutin.
- Pregnancy: avoid because safety is not established.
- Breast-feeding: no contra-indication.
Source
MSF Essential drugs practical guidelines (January 2026)
This page combines source-derived medicine reference sections with Kenza editorial context, while leaving out the Storage and Remarks sections from the source batch.
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