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31 August 2026Chapter 3: Gastrointestinal disordersPDF page 126

Oral and oropharyngeal candidiasis

Full paraphrased clinical guide to oral thrush, risk factors, treatment, recurrence, and HIV/diabetes considerations.

This guide supports clinical education and care navigation. It does not replace bedside judgement, emergency care, specialist advice, or local treatment protocol.

Seek urgent care

  • Difficulty swallowing, painful swallowing, dehydration, inability to feed, or extensive disease.
  • Frequent recurrence, severe spread, weight loss, fever, or suspected HIV, diabetes, or immune suppression.
  • Thrush in a very young infant with poor feeding or signs of systemic illness.

Overview and risk factors

Oral candidiasis is usually caused by Candida albicans.

It is common in infants and also occurs in immunocompromised or diabetic patients.

  • Risk is increased by oral antibiotics and high-dose inhaled corticosteroids.
  • Frequent recurrence or oesophageal symptoms should prompt assessment for HIV or other immune compromise.

Clinical features

  • White patches on the tongue and inside the cheeks.
  • Patches may spread toward the pharynx.
  • Swallowing difficulty or pain suggests more extensive disease.

Treatment

  • Apply nystatin suspension or miconazole gel between meals; keep in the mouth for 2 to 3 minutes, then swallow.
  • In young children, apply to the tongue and inside each cheek and show the caregiver how to do this safely at home.
  • Assess hydration and feeding; provide fluid and nutrition support if mouth pain or swallowing symptoms limit intake.
  • In immunocompromised patients or patients with frequent, extensive, or oesophageal disease, assess and manage the underlying condition, especially HIV or diabetes.
  • Handover should include age, feeding ability, lesion extent, swallowing pain, diabetes/HIV risk, recent antibiotics or inhaled corticosteroids, medicine chosen, caregiver technique, and review plan.
Local antifungal treatment for 7 days
MedicineDose
Nystatin oral suspensionChildren and adults: 400 000 IU daily, commonly 1 ml of 100 000 IU/ml suspension four times daily.
Miconazole oral gelChildren 6 months to 2 years: 1.25 ml four times daily. Children over 2 years and adults: 2.5 ml four times daily.

Medicines in this guide

Source

MSF Clinical guidelines - Diagnosis and treatment manual (December 2024)

This page is a paraphrased clinician-oriented guide derived from the source topic on PDF page 126. Medicine-specific details should be checked against local protocol and the linked drug-information pages.